Systemic lupus erythematosus is an autoimmune disease that affects many systems, including the skin, musculoskel. New acr, eular criteria distinguish lupus from imitators. Hydroxychloroquine is the cornerstone of treatment because it reduces disease flares and other constitutional symptoms. Systemic lupus erythematosus is a chronic autoimmune condition that causes inflammation in the bodys tissues. Although both men and women of all age groups can be affected, women outnumber men almost 10 fold and. Systemic lupus erythematosus, the most common form of lupus, is a chronic autoimmune disease that can cause severe fatigue and joint pain. Diagnostic criteria for systemic lupus erythematosus. Thus, a patient who presents with skin and joint disease remains at risk for renal disease even after having lupus.
The most recent addendum to the classification criteria for sle dates from 2012, when the systemic lupus international collaborating clinics slicc group published a revision and validation of the acr criteria 5. Indeed, it is the diversity of presentation, accumulation of manifestations over time, and undulating disease course that challenge the most astute of clinicians. The slicc group is an international group of investigators dedicated to clinical research on sle. Pathogenesis 20 and clinical features 1 introduction. Discoid rash raised erythematous patches with keratotic scaling, follicular plugging, and atrophic scarring 3. Systemic lupus erythematosus is a disease that continues to evolve over time. Systemic lupus erythematosus sle is a spectrum of autoimmune disease in which defects can occur at multiple points of the immune cascade, resulting in a striking heterogeneity of clinical. If a patient meets at least four criteria, lupus can be diagnosed with 95% specificity and 85% sensitivity. The 2012 revised slicc criteria for classification of. In the validation cohort, the new criteria had a sensitivity of 96. With rare exception, the unifying laboratory abnormality is. The diagnostic accuracies of the 2012 slicc criteria and. Systemic lupus erythematosus sle is a chronic, multisystem autoimmune disease characterized by disorder of the generation of autoantibodies to components of cell nucleus, and the exact. All patients with lupus should receive education, counseling, and support.